Ribonucleotide reductase and cancer
WebbIn this study, known antimetabolite drugs such as gemcitabine (ribonucleotide reductase inhibitor) and 5-fluorouracil (thymidylate synthase inhibitor) were compared with novel members of these two drug families in the treatment of a chemoresistant pancreatic cancer cell line PANC-1. Webb31 mars 2024 · Overall, these data implicate IGF1R in alleviating replication stress, and the reciprocal IGF:ATM codependence we identify provides an approach to exploit this effect in ATM-deficient cancers. Significance: This study identifies regulation of ribonucleotide reductase function and dNTP supply by IGFs and demonstrates that IGF axis blockade …
Ribonucleotide reductase and cancer
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Webb31 aug. 2024 · Ribonucleotide reductase, an enzyme required for DNA synthesis and repair, is overexpressed in many cancers and associated with poor prognosis. Here, we investigate the biological significance of ribonucleotide reductase subunit M1 (RRM1) in multiple myeloma cells. Webb16 jan. 2024 · Ribonucleotide reductase subunit M2 (RRM2) is associated with the biological behaviours of cancers, including apoptosis, cell proliferation, invasion, cell cycle and migration. Previous studies have suggested that the expression of RRM2 plays critical roles in tumorigenesis in several cancer types.
Webb31 mars 2024 · Supplementary Data from Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase Dysfunction. Rieunier G., Wu X., Harris LE., Mills JV., Nandakumar A., Colling L., Seraia E., Hatch SB ... Division of Cancer Medicine; 60 seconds with... Oncology Executive Committee (OEC) Working with us. Family Friendly; Training ... Webb10 juni 2024 · Ribonucleotide reductase (RR) is an essential multi-subunit enzyme found in all living organisms; it catalyzes the rate-limiting step in dNTP synthesis, namely, the …
WebbN2 - The appropriate supply of dNTPs is critical for cell growth and genome integrity. Here, we investigated the interrelationship between dUTP pyrophosphatase (dUTPase) and ribonucleotide reductase (RNR) in the regulation of genome stability. Our results demonstrate that reducing the expression of dUTPase increases genome stress in cancer. WebbDysregulated RR activity is associated with genomic instability, malignant transformation and cancer development. The use of RR inhibitors, either as a single agent or combined …
Webb6 mars 2006 · Ribonucleotide reductase catalyzes a crucial step in de novoDNA synthesis and is allosterically controlled by relative levels of dNTPs to maintain a balanced pool of deoxynucleoside triphosphates in the cell. In eukaryotes, the enzyme comprises a heterooligomer of α2and β2subunits. The α subunit, Rnr1, contains catalytic and …
WebbWO2024043923A1 PCT/US2024/043660 US2024043660W WO2024043923A1 WO 2024043923 A1 WO2024043923 A1 WO 2024043923A1 US 2024043660 W … bambi hat fnfWebb17 mars 2014 · RRM2 is a new molecular marker for the diagnosis and clinical outcomes of cervical cancer. It is involved in cervical carcinogenesis and predicts poor survival, and may be a potential therapeutic target including in cisplatin treatment. bambi happy mealWebb6 dec. 2016 · This is achieved in part by upregulation of ribonucleotide reductase (RNR) activity which occurs by various mechanisms, including allosteric activation, increased levels of RNR expression, altered cellular localisation of RNR subunits, and proteolysis of RNR inhibitory proteins (reviewed in [21,22,23,24]). arnel\u0027s takeawayWebb31 mars 2024 · Supplementary methods, Table S1-S2, Figure S1-S6 bambi hansenWebb20 juli 2024 · Tumor suppressor genes can be silenced genetically as well as epigenetically. One approach to reversing epigenetic suppression of tumor suppressor genes is to inhibit DNA methyl transferase. 5-aza-2′,2′-difluorodeoxycytidine (NUC013) is a novel DNA methyl transferase and ribonucleotide reductase inhibitor that is a more … bambiha meaning in punjabiWebbN2 - Ribonucleotide reductase ... Together, our results revealed a previously unrecognized reciprocal regulation between dNTP pools and autophagy in cancer cells. AB - Ribonucleotide reductase (RNR) plays a critical role in catalyzing the biosynthesis and maintaining the intracellular concentration of 4 deoxyribonucleoside triphosphates … bambi hellscape gamebananaWebbTMU Research Center of Cancer Translational Medicine, Taipei Medical University Yi-Fan Chen ... Ribonucleotide reductase M2B (Rrm2b) modulates MuSC quiescence/differentiation in muscle in response to injury. Rrm2b knockout in myofibers, but not in MuSCs, led to weakness of muscles, such as a loss of muscle mass and … bambi hase