Witryna5 lis 2024 · IMR-687 (tovinontrine) is a highly selective phosphodiesterase 9 (PDE9) inhibitor being developed as an orally administered therapy for patients with sickle cell disease (SCD) and beta-thalassemia. IMR-687 increases intracellular cGMP levels and has been shown in preclinical studies to increase fetal hemoglobin (HbF) expression … Witryna8 gru 2024 · Melikian et al 21 found a mean IMR of 19±5 in 15 patients without coronary disease or risk factors for coronary disease referred to the cardiac catheterization laboratory for a noncoronary reason. Luo et al 22 performed a similar study and found a similar mean IMR of 19±5.6 in 18 patients without coronary disease or risk factors.
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Witryna11 cze 2024 · Imara is currently advancing IMR-687, a highly selective, potent small molecule inhibitor of PDE9 that is an oral, once-a-day, potentially disease-modifying … Witryna10 cze 2024 · In a patient presenting with symptoms of ischaemia, cardiac enzyme elevation and echocardiographic or electrocardiographic features suggestive of acute MI, a working diagnosis is made during angiography in the absence of culprit obstructive coronary artery disease (epicardial coronary artery stenosis ≥50%) or an apparent … dashes and grids in the devil made me do it
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Witryna26 maj 2024 · Coronary microvascular dysfunction (CMD) is a prevalent cause of ischemic heart disease and is associated with poorer quality of life and worse patient outcomes. Both functional and structural abnormalities of the microcirculation can generate ischemia in the absence of epicardial stenosis or worsen concomitant … Witryna12 kwi 2024 · The index of microcirculatory resistance (IMR), based on the thermodilution principle, was introduced nearly 20 years ago to investigate microvascular hemodynamics in patients with ischemic heart disease (IHD) 9, 10, 11. More recently, we have proposed a novel wire-free coronary angiography-derived index of … Witryna9 lut 2024 · Thermodilution-derived index of microvascular resistance (IMR) represents a more precise metric of microvascular function. 6 When measures of CFR and IMR are collected concurrently, it is evident that patients with a low CFR can also present with a low IMR (low CFR/low IMR) or high IMR (low CFR/high IMR). 7 This is relevant … bitdefender web access control